Biomaterial Database

Myocardial blood flow and oxygen consumption during halothane-nitrous oxide anaesthesia for coronary revascularization. 1983

O Hilfiker, and R Larsen, and H Sonntag

The effects of halothane on myocardial blood flow and myocardial oxygen balance were studied in seven male patients with stable angina and normal left ventricular function. Patients were receiving maintenance doses of beta-receptor antagonists and underwent coronary artery bypass surgery. Anaesthesia consisted of halothane and 50% nitrous oxide in oxygen. Halothane decreased myocardial blood flow and myocardial oxygen consumption by 29% and 32%, respectively, after induction of anaesthesia, and during sternotomy. Myocardial lactate production was not observed at any time. Cardiac index, stroke volume index, mean arterial pressure and mean diastolic arterial pressure were decreased significantly after induction of anaesthesia and during sternotomy. Heart rate remained unchanged. The global myocardial oxygen supply and demand relationship was maintained. The results suggest that halothane is a safe anaesthetic for coronary revascularization in patients with unimpaired left ventricular function.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D009609	Nitrous Oxide	Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.	Laughing Gas,Nitrogen Protoxide,Gas, Laughing,Oxide, Nitrous
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D003326	Coronary Circulation	The circulation of blood through the CORONARY VESSELS of the HEART.	Circulation, Coronary
D006221	Halothane	A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)	1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man