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The effects of single oral administration of 1,2,4-trichlorobenzene (TCB), 200, 400, 800 or 1600 mg/kg, and of daily oral administration of TCB, 400 mg/kg, for 3 consecutive days, on components of the microsomal monooxygenase system, glutathione, and the activities of cytosolic glutathione S-transferase and microsomal epoxide hydrolase in Japanese quail liver were studied. Cytochromes P-450 and b5 contents of liver microsomes and the activities of 7-ethoxyresorufin deethylase (7-ERD) and glutathione S-transferase were significantly increased 1 day after administration of single doses of TCB. Liver GSH and 7-ethoxycoumarin deethylase (7-ECD) activity were unchanged. Microsomal epoxide hydrolase activity was significantly decreased at TCB doses above 400 mg/kg. Increases in cytochromes and activities of 7-ERD and glutathione S-transferase were also seen following the 3-day administration of TCB, 400 mg/kg. In addition, liver GSH and the activity of NADPH-cytochrome c reductase were significantly increased whereas 7-ECD was significantly decreased by the 3-day treatment. These findings indicate that in Japanese quail, TCB is an inducer of 7-ERD and glutathione S-transferase but not of 7-ECD and epoxide hydrolase.
C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
October 1993,
Toxicology and applied pharmacology,
C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
December 1999,
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C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
January 2000,
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C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
March 1974,
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C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
April 1976,
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C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
April 1985,
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C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
March 1962,
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C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
January 1980,
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C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
December 1987,
Environmental research,
C L Miranda, and
J L Wang, and
M C Henderson, and
H M Carpenter, and
H S Nakaue, and
D R Buhler
February 1975,
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