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Human platelet membranes were isolated by the glycerol-lysis technique. When tested by a turbidimetric method in the presence of fibrinogen and calcium ions, the membrane vesicles exhibited patterns of reactivity to collagen. As with human platelet-rich plasmas, the aggregating effects of collagen were inhibited by preincubating the membrane suspensions with hemolytically active human C1q. Upon addition to platelet-rich plasma, the isolated membranes reduced collagen-provoked platelet aggregation. This inhibitory effect was partially suspended by prior incubation of the membranes with native C1q. The results show that the receptors for collagen and C1q are preserved during the membrane isolation procedure and support the competitive nature of inhibition by C1q of collagen-induced platelet aggregation.
G Csákó, and
E A Suba, and
S H Ohanian
January 1986,
Acta biochimica Polonica,
G Csákó, and
E A Suba, and
S H Ohanian
February 1989,
The Biochemical journal,
G Csákó, and
E A Suba, and
S H Ohanian
August 1990,
Thrombosis research,
G Csákó, and
E A Suba, and
S H Ohanian
August 1987,
Thrombosis and haemostasis,
G Csákó, and
E A Suba, and
S H Ohanian
November 1983,
Thrombosis research,
G Csákó, and
E A Suba, and
S H Ohanian
November 1990,
Journal of immunology (Baltimore, Md. : 1950),
G Csákó, and
E A Suba, and
S H Ohanian
January 1980,
The Journal of laboratory and clinical medicine,
G Csákó, and
E A Suba, and
S H Ohanian
March 1985,
Thrombosis research,
G Csákó, and
E A Suba, and
S H Ohanian
July 1976,
Journal of immunology (Baltimore, Md. : 1950),
G Csákó, and
E A Suba, and
S H Ohanian
November 1996,
Infection and immunity,
