BIOMAT Database Logo BIOMAT Database Logo

Genetic markers for acute anterior uveitis. 1983

S A LeClercq, and J S Percy, and A S Russell

One hundred and sixty-nine patients, 82 with acute anterior uveitis (AAU) only, 48 with AAU and ankylosing spondylitis (AS), and 39 with AS only were studied. The HLA antigen A2 was present in 44/82 AAU only, 31/48 AAU + AS, and 23/39 AS only. Where haplotype analysis was possible by virtue of family studies, A2 B27 was present in 7/16 AAU only, 9/15 AAU and AS and 14/29 AS only. These figures do not differ significantly from the expected values of control populations. Alpha-1-antitrypsin (alpha-1-AT) phenotypes were obtained on 30/82 AAU only, 29/48 AAU + AS, and 27/39 AS only patients. The MZ phenotype appeared in 8/86 patients tested; 4/30 with AAU only and 4/29 AAU + AS patients. This is higher than the expected value for control populations. Therefore, MZ alpha-1-AT phenotype but not HLA-A2 appears increased in patients with AAU.

UI MeSH Term Description Entries
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D005819 Genetic Markers A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event. Chromosome Markers,DNA Markers,Markers, DNA,Markers, Genetic,Genetic Marker,Marker, Genetic,Chromosome Marker,DNA Marker,Marker, Chromosome,Marker, DNA,Markers, Chromosome
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014606 Uveitis, Anterior Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced. Anterior Uveitides,Anterior Uveitis,Uveitides, Anterior
D015789 HLA-A2 Antigen A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family. HLA Class I Histocompatibility Antigen, A-2 alpha Chain,HLA-A2,Antigen, HLA-A2,HLA A2 Antigen,HLA Class I Histocompatibility Antigen, A 2 alpha Chain
D015796 HLA-B27 Antigen A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family. HLA Class I Histocompatibility Antigen, B-27 alpha Chain,HLA-B27,Antigen, HLA-B27,HLA B27 Antigen,HLA Class I Histocompatibility Antigen, B 27 alpha Chain

Related Publications

S A LeClercq, and J S Percy, and A S Russell
Genetic background of acute anterior uveitis.
June 1981, American journal of ophthalmology,
S A LeClercq, and J S Percy, and A S Russell
TNF-857T, a genetic risk marker for acute anterior uveitis.
May 2005, Investigative ophthalmology & visual science,
S A LeClercq, and J S Percy, and A S Russell
Chemokine receptors and early activation markers in acute anterior uveitis.
April 2004, Acta ophthalmologica Scandinavica,
S A LeClercq, and J S Percy, and A S Russell
Acute anterior uveitis.
August 2009, BMJ (Clinical research ed.),
S A LeClercq, and J S Percy, and A S Russell
Uveitis (acute anterior).
April 2010, BMJ clinical evidence,
S A LeClercq, and J S Percy, and A S Russell
Acute anterior uveitis.
June 2003, Clinical evidence,
S A LeClercq, and J S Percy, and A S Russell
Acute anterior uveitis.
June 2002, Clinical evidence,
S A LeClercq, and J S Percy, and A S Russell
Acute anterior uveitis.
December 2003, Clinical evidence,
S A LeClercq, and J S Percy, and A S Russell
Acute anterior uveitis.
December 2005, Clinical evidence,
S A LeClercq, and J S Percy, and A S Russell
Acute anterior uveitis.
December 2004, Clinical evidence,
Copied contents to your clipboard!