-transparent.png){kind=logo}
Twenty-six evaluable patients with advanced soft tissue and bony sarcomas refractory to chemotherapy were treated with vincristine plus high-dose methotrexate and leucovorin rescue. A 14% response rate was observed among 14 patients presenting with refractory soft tissue sarcomas. No responses were observed among 12 patients with bony sarcoma. Toxic reaction with nausea, vomiting, nephrotoxicity, and myelosuppression was manageable. While this study did demonstrate activity of this regimen in doxorubicin-refractory patients, the duration of the responses was relatively brief. Thus, the clinical utility of such a regimen is questionable.
Related Publications
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
August 1978,
Cancer nursing,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
December 1978,
American journal of veterinary research,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
February 1979,
Cancer treatment reports,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
February 1988,
The Journal of rheumatology,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
November 1974,
JAMA,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
March 1979,
Cancer research,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
January 1985,
Cancer chemotherapy and pharmacology,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
January 1980,
Cancer treatment reports,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
January 1981,
Cancer treatment reports,
C B Vaughn, and
E McKelvey, and
S P Balcerzak, and
K Loh, and
R Stephens, and
L Baker
September 2022,
Journal of clinical pharmacy and therapeutics,
