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The circadian variations in circulating T cell subsets defined by monoclonal antibodies in eight healthy male volunteers were evaluated in whole blood using a flow cytometry. In all subjects, the number of lymphocytes showed a clear rhythmicity with high values at night and low values during the day. This circadian variation in circulating lymphocytes appeared to reflect largely a change in the number of T cells rather than B cells. The percentage of OKT3+ and OKT11+ cells showed a similar fluctuation with a peak at night and a depression during the day. It was found that the percentage of OKT4+ cells varied in parallel with that of T cells, particularly of OKT3+ cells, but the OKT8+ subset was not appreciably altered over a 24 h period. Thus, a circadian variation of T cells could be largely accounted for by a circadian change of OKT4+ cells. Plasma cortisol levels showed an expected circadian variation. It was also shown that there might be an intimate relationship between these circadian changes of T cell subsets and plasma cortisol levels.
T Miyawaki, and
K Taga, and
T Nagaoki, and
H Seki, and
Y Suzuki, and
N Taniguchi
September 1984,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
T Miyawaki, and
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Zhonghua fu chan ke za zhi,
T Miyawaki, and
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Sexually transmitted infections,
T Miyawaki, and
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T Miyawaki, and
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February 1983,
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T Miyawaki, and
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T Miyawaki, and
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July 2002,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
T Miyawaki, and
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T Miyawaki, and
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March 1987,
Sarcoidosis,
T Miyawaki, and
K Taga, and
T Nagaoki, and
H Seki, and
Y Suzuki, and
N Taniguchi
January 1984,
Clinical and experimental rheumatology,
