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The cellular requirement(s) and mechanism(s) involved in the augmentation of human natural killer cell (NK) activity by Interleukin (IL-2) were studied. NK activity was enhanced by IL-2 in the absence of monocytes. This potentiation of IL-2 on NK enhancement was suppressed by PGE2, and was enhanced by indomethacin in the experiments using unfractionated mononuclear cells. When monocyte-depleted cells were stimulated with IL-2, the cytotoxic activity was greater than that seen with unfractionated mononuclear cells. Monocytes in culture produced PGE2 which partially reduced NK enhancement by IL-2. These findings suggest that PGE2, produced by monocytes, regulates the NK enhancement by IL-2 in vitro.
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
March 1986,
Journal of immunology (Baltimore, Md. : 1950),
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
February 1985,
Cellular immunology,
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
March 1985,
Cellular immunology,
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
April 1983,
Journal of immunology (Baltimore, Md. : 1950),
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
August 1984,
Cancer research,
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
May 1981,
Nature,
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
June 1985,
Cellular immunology,
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
January 1990,
Natural immunity and cell growth regulation,
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
October 1987,
Cellular immunology,
H Suzuki, and
N Yamashita, and
E Sugiyama, and
M Sato, and
M Ito, and
S Yano
January 1986,
Clinical and experimental immunology,
