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Cell surface antigen phenotypes of MCF-induced thymic lymphomas in AKR mice. 1984

R A Yetter, and H C Morse

The hypothesis that the surface antigen phenotypes of MCF-MuLV-induced thymic lymphomas in AKR mice are predictable and characteristic of the inducing virus has been tested. Thymic lymphomas induced by two different MCF-MuLV were assayed by flow microfluorometry for their expression of the surface antigens XenCSA, Thy-1.1, Ly-2, Ly-1, 2C2, H-2K, and Ia. In all cases there was an increase in XenCSA levels. The lymphomas could be divided into three categories on the basis of qualitative difference in Ly-2 expression: Ly-2+ tumors, Ly-2- tumors, and tumors with both Ly-2+ and Ly-2- populations. One lymphoma expressed 2C2, an antigen not normally found on thymocytes. Quantitative differences in expression could be found for all antigens. This variation in surface antigen phenotype was independent of the cloned virus MCF used to induce the lymphoma.

UI MeSH Term Description Entries
D008223 Lymphoma A general term for various neoplastic diseases of the lymphoid tissue. Germinoblastoma,Lymphoma, Malignant,Reticulolymphosarcoma,Sarcoma, Germinoblastic,Germinoblastic Sarcoma,Germinoblastic Sarcomas,Germinoblastomas,Lymphomas,Lymphomas, Malignant,Malignant Lymphoma,Malignant Lymphomas,Reticulolymphosarcomas,Sarcomas, Germinoblastic
D008806 Mice, Inbred AKR An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. Mice, AKR,Mouse, AKR,Mouse, Inbred AKR,AKR Mice,AKR Mice, Inbred,AKR Mouse,AKR Mouse, Inbred,Inbred AKR Mice,Inbred AKR Mouse
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D002472 Cell Transformation, Viral An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus. Transformation, Viral Cell,Viral Cell Transformation,Cell Transformations, Viral,Transformations, Viral Cell,Viral Cell Transformations
D000406 AKR murine leukemia virus A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from spontaneous leukemia in AKR strain mice. AKR Virus,Gross Virus,AKR Viruses,Virus, AKR,Virus, Gross,Viruses, AKR
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000951 Antigens, Neoplasm Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin. Neoplasm Antigens,Tumor Antigen,Tumor Antigens,Antigen, Tumor,Antigens, Tumor
D000954 Antigens, Surface Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated. Cell Surface Antigens,Surface Antigens,Surface Markers, Immunological,Cell Surface Antigen,Immunologic Surface Markers,Markers, Immunological Surface,Surface Antigen,Surface Markers, Immunologic,Antigen, Cell Surface,Antigen, Surface,Antigens, Cell Surface,Immunological Surface Markers,Markers, Immunologic Surface,Surface Antigen, Cell,Surface Antigens, Cell
D013953 Thymus Neoplasms Tumors or cancer of the THYMUS GLAND. Cancer of Thymus,Thymus Cancer,Thymus Tumors,Cancer of the Thymus,Neoplasms, Thymic,Neoplasms, Thymus,Thymic Cancer,Thymic Neoplasms,Thymic Tumors,Cancer, Thymic,Cancer, Thymus,Cancers, Thymic,Cancers, Thymus,Neoplasm, Thymic,Neoplasm, Thymus,Thymic Cancers,Thymic Neoplasm,Thymic Tumor,Thymus Cancers,Thymus Neoplasm,Thymus Tumor,Tumor, Thymic,Tumor, Thymus,Tumors, Thymic,Tumors, Thymus
D015478 Antigens, Heterophile Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species. Antigens, Heterogenetic,Antigens, Xenogeneic,H-D Antigens,Hanganutziu-Deicher Antigen,Hanganutziu-Deicher Antigens,Heteroantigens,Heterologous Antigen,Heterologous Antigens,Heterophile Antigen,Heterophile Antigens,Paul-Bunnell Antigens,Xenoantigen,Xenoantigens,Antigens, Heterologous,Antigens, Heterophil,Antigens, Xenogenic,Heterogenetic Antigens,Antigen, Hanganutziu-Deicher,Antigen, Heterologous,Antigen, Heterophile,Antigens, H-D,Antigens, Hanganutziu-Deicher,Antigens, Paul-Bunnell,H D Antigens,Hanganutziu Deicher Antigen,Hanganutziu Deicher Antigens,Heterophil Antigens,Paul Bunnell Antigens,Xenogeneic Antigens,Xenogenic Antigens

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