-transparent.png){kind=logo}
The in vitro inhibitory activity of Lonidamine on the aerobic glycolysis of normal as well as leukemic lymphocytes has been investigated. The extent of the impairment of lactate production induced by Lonidamine on normal thymus (T)- and bone marrow (B)-derived lymphocytes was found to be dependent on their source of origin, i.e. residing or circulating pool. Among leukemia tested 'null' and B cell leukemias appeared the most affected metabolically by the compound. Administration in vivo of the drug to the patient with B cell chronic leukemia resulted in a decrease of lactate production by leukemic cells comparable to that induced in vitro. These metabolic changes were paralleled in normal, as well as in leukemic cells by ultrastructural lesions, mainly confined to the mitochondrial compartment.
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
November 1997,
Journal of photochemistry and photobiology. B, Biology,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
January 1979,
Archives of andrology,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
March 1978,
Journal of reproduction and fertility,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
June 1979,
Archives of andrology,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
January 1979,
Cytobios,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
December 1953,
Zeitschrift fur Rheumaforschung,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
March 1981,
Journal of the National Cancer Institute,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
February 1962,
Biochemical pharmacology,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
May 2001,
Biology of reproduction,
P G Natali, and
F Salsano, and
M Viora, and
A Nista, and
W Malorni, and
A Marolla, and
C De Martino
April 1985,
Experimental and molecular pathology,
