-transparent.png){kind=logo}
T-cell growth factor (interleukin 2) was partially purified from the conditioned medium from Con A-stimulated rat splenocytes. It had the molecular weight of 23,000 according to gel filtration and in the range of 17,000-18,000 daltons according to PAGE in the presence of SDS. The molecular forms of IL 2 exhibited isoelectric points (pI) of 5.4-5.8 (major peak), 4.3-4.5 and 6.5-6.8 (minor peaks). T-cell growth-promoting activity was remarkably stable to temperature, pH, SDS and 2-ME treatments. Rat IL 2 did not bind to immobilized Con A, WGA, RC 1, and fucose-binding protein. The conditioned medium also contained the inhibitor of IL 2-dependent T-cell proliferation.
Related Publications
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
January 1981,
Immunology today,
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
December 1980,
Journal of immunology (Baltimore, Md. : 1950),
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
June 1986,
Proceedings of the National Academy of Sciences of the United States of America,
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
March 1982,
European journal of immunology,
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
December 1980,
Immunology today,
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
April 1988,
European journal of immunology,
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
March 1982,
The Journal of experimental medicine,
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
December 1981,
Transplantation proceedings,
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
August 1989,
Proceedings of the National Academy of Sciences of the United States of America,
V A Nesmeyanov, and
T I Valyakina, and
A P Alexenko, and
N V Lavrova, and
O E Lakhtina, and
E E Chikirdina, and
V A Kulshin
February 1983,
Cellular immunology,
