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The effect of 2'-deoxycoformycin (DCF) on the PFC responses of AKR mice to SE, TNP-Ficoll, and TNP-B. abortus was examined. Subcutaneous injection of DCF 4 days before antigen caused suppression of all three responses by 70 to 78%. In contrast, injection of DCF 1 day after antigen caused enhancement of both the anti-SE and the anti-TNP-Ficoll responses. Although a single high dose of cortisone acetate injected 4 days before antigen caused a similar suppression, the effect of DCF was not mediated via a steroid release, inasmuch as DCF also suppressed the immune response in adrenalectomized mice. The response of BALB/c mice to TNP-Ficoll was also inhibited by DCF pretreatment and enhanced by injection of DCF after antigen. In contrast, in athymic mice DCF caused suppression of the anti-TNP-Ficoll PFC response, whether injected before or after antigen. These results are interpreted as suggesting that DCF causes suppression primarily via an effect on B cells. The enhancement seen in normal but not in athymic mice may possibly be ascribed to an effect on suppressor T cells. Apparently the enhancement of both TD and TI responses caused by DCF injected 1 day after antigen in normal mice is the net result of these two opposing effects. The results imply that helper T cells are resistant to DCF.
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
June 1992,
The Journal of infectious diseases,
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
June 1985,
Journal of immunology (Baltimore, Md. : 1950),
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
July 1971,
Immunology,
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
February 1978,
Immunology,
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
July 1990,
Infection and immunity,
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
November 1984,
Journal of immunology (Baltimore, Md. : 1950),
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
January 1974,
International archives of allergy and applied immunology,
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
December 1986,
European journal of immunology,
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
March 1993,
Proceedings of the National Academy of Sciences of the United States of America,
H Ratech, and
M K Bell, and
R Hirschhorn, and
G J Thorbecke
February 1981,
British journal of experimental pathology,
