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2- and 3-18F-fluoro-deoxy-D-glucose were proposed as sugar analogs to study glucose metabolism in brain and heart tissues. To evaluate their usefulness, the in vivo behavior of 2- 28FDG and 3-18FDG was investigated in mice and rats and for 3-18FDG in dogs at various times post-injection. Positron emission tomographic (PET) imaging was performed for heart and brain of anesthetized dogs with both radiopharmaceuticals. In all species studied, a higher uptake in brain, heart and kidney was observed for 2-18FDG compared with 3-18FDG. Radioactivity also cleared blood and liver more rapidly with 2-18FDG than with 3-18FDG. Estimates of brain kinetic model parameters revealed the metabolic trapping of 2-18FDG, making this agent favorable for studies of tissue metabolism, and the relative lack of phosphorylation of 3-18FDG, which makes it a potential agent for studies of glucose transport.
K J Kearfott, and
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J A Correia, and
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R H Ackerman, and
G L Brownell, and
W H Strauss
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European journal of nuclear medicine,
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G L Brownell, and
W H Strauss
January 1986,
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K J Kearfott, and
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November 1983,
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K J Kearfott, and
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G L Brownell, and
W H Strauss
September 1987,
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K J Kearfott, and
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October 1990,
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K J Kearfott, and
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W H Strauss
December 2016,
Chinese medical journal,
K J Kearfott, and
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January 2008,
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K J Kearfott, and
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February 2003,
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K J Kearfott, and
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W H Strauss
January 1977,
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K J Kearfott, and
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W H Strauss
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Molecular imaging and biology,
