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Sister chromatid exchange (SCE) rates in 10 long-term lead-exposed men increased significantly with increasing zinc protoporphyrin concentration in blood. SCE rates were also related to blood lead levels, but this correlation was not statistically significant. These results were obtained before the summer vacation. Six men were examined again shortly after the vacation; both SCE rates and lead-exposure parameters had decreased significantly. An increase was seen in one worker; however, this result could be related to a serious disease for which he was undergoing treatment. Continued examinations showed a tendency of increasing SCE rates and exposure parameters, but the follow-up was too incomplete to allow a statistical analysis. Further studies of 18 newly employed workers failed to show any increase in SCE during the first 4 months of employment despite some increases in both zinc protoporphyrin and lead levels in the blood. The results obtained suggest that a genotoxic effect due to inorganic lead may occur in long-term lead-exposed workers.
P Grandjean, and
H C Wulf, and
E Niebuhr
January 1987,
La Medicina del lavoro,
P Grandjean, and
H C Wulf, and
E Niebuhr
January 1992,
International archives of occupational and environmental health,
P Grandjean, and
H C Wulf, and
E Niebuhr
January 1977,
Annual review of genetics,
P Grandjean, and
H C Wulf, and
E Niebuhr
January 2005,
Current protocols in cell biology,
P Grandjean, and
H C Wulf, and
E Niebuhr
January 1987,
Boletin de estudios medicos y biologicos,
P Grandjean, and
H C Wulf, and
E Niebuhr
January 1998,
Biological trace element research,
P Grandjean, and
H C Wulf, and
E Niebuhr
October 1984,
Mutation research,
P Grandjean, and
H C Wulf, and
E Niebuhr
January 1989,
Biulleten' eksperimental'noi biologii i meditsiny,
P Grandjean, and
H C Wulf, and
E Niebuhr
January 2002,
Chemosphere,
P Grandjean, and
H C Wulf, and
E Niebuhr
January 1982,
Cytogenetics and cell genetics,
