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Postpartum uterine pressures were measured in healthy women with an intrauterine microballoon before, during, and after administration of different concentrations of halothane or enflurane. Arterial blood samples for anesthetic levels were obtained at intervals. Frequency and intensity of contractions diminished markedly when blood levels exceeded the equivalent of 1/2 MAC (minimum alveolar anesthetic concentration which produces immobility in one-half of subjects exposed to a noxious stimulus) of nonpregnant adults, but normal patterns returned promptly on lightening of anesthesia. Response to 10 mU of oxytocin was suppressed at blood levels corresponding to between 3/4 and 1 MAC of the agents. Halothane and enflurane exert equipotent dose-related reversible effects on the activity of the full-term pregnant human uterus.
G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
January 1972,
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G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
October 1970,
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G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
March 1965,
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G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
January 1974,
Anesthesia and analgesia,
G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
April 1974,
JAMA,
G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
April 1978,
British journal of anaesthesia,
G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
December 1971,
Nordisk medicin,
G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
February 1975,
Anesthesiology,
G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
November 1977,
Annals of ophthalmology,
G F Marx, and
Y I Kim, and
C C Lin, and
S Halevy, and
H Schulman
February 1979,
Anesthesiology,
