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CT examination of the central nervous system was performed in 19 patients with acquired immunodeficiency syndrome (AIDS). Eighteen patients were homosexuals, and five drug abusers. Parenchymal and meningeal inflammations were seen in patients with intracranial manifestations of the disease. The most common demonstrable lesion in the parenchyma was toxoplasmosis, which produced ring enhancement, solid enhancement, and nonenhancing focal edema. The most common meningeal inflammation was cryptococcosis, which was diagnosed by examination of the cerebrospinal fluid and did not show specific CT changes. It is concluded that toxoplasmosis and cryptococcosis should be the first diagnostic consideration in patients with neurologic findings who have a history of homosexuality and/or intravenous drug abuse and previous unusual infections or anergy. A delayed contrast scan, single or double dose, appears to be the most accurate method of outlining the total extent of disease thereby helping to locate the best biopsy site for pretreatment diagnosis. Empirical institution of toxoplasmosis therapy is recommended in those cases in which CT findings are consistent with toxoplasmosis and the biopsy shows only nonspecific encephalitis. A biopsy of every parenchymal lesion is not considered necessary.
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
January 1985,
JAMA,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
January 1986,
Acta radiologica: diagnosis,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
January 1989,
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
May 2009,
Cases journal,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
January 1988,
The Annals of otology, rhinology, and laryngology,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
January 1992,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
January 1985,
Revue de stomatologie et de chirurgie maxillo-faciale,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
January 1988,
Journal francais d'ophtalmologie,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
March 2000,
Archives of internal medicine,
M A Whelan, and
I I Kricheff, and
M Handler, and
V Ho, and
K Crystal, and
G Gopinathan, and
L Laubenstein
September 2020,
Cureus,
