Biomaterial Database

Vitamin B12 binding proteins (transcobalamin and haptocorrin) in serum and synovial fluid of patients with rheumatoid arthritis and traumatic synovitis. 1983

P A Christensen, and J Brynskov, and P Gimsing, and J Petersen

The vitamin B12 (cobalamin) binding proteins, transcobalamin and haptocorrin, were measured in serum and synovial fluid of 12 patients with rheumatoid arthritis (RA) and 11 patients with traumatic synovitis (TS). Levels of both the cobalamin-binding proteins of synovial fluid were markedly elevated in RA compared with TS. In serum, the haptocorrin concentrations were significantly increased in RA vis-à-vis TS. In synovial fluid of RA patients, the transcobalamin and haptocorrin concentrations were positively correlated to the concentrations of macrophages and polymorphonuclear granulocytes, respectively. The demonstration of increased synovial fluid transcobalamin/total protein and haptocorrin/total protein ratios in RA vis-à-vis TS provides further evidence of a local production or liberation of the cobalamin-binding proteins in synovial fluid of patients with RA.

UI	MeSH Term	Description	Entries
D008264	Macrophages	The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)	Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D006098	Granulocytes	Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.	Granulocyte
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis
D013582	Synovial Fluid	The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.	Synovia,Fluid, Synovial,Fluids, Synovial,Synovial Fluids
D013585	Synovitis	Inflammation of the SYNOVIAL MEMBRANE.	Plica Syndrome,Synovial Plica Syndrome,Synovial Hypertrophy,Synovial Thickening,Hypertrophies, Synovial,Hypertrophy, Synovial,Plica Syndrome, Synovial,Synovial Hypertrophies,Synovial Thickenings,Synovitides,Thickening, Synovial,Thickenings, Synovial
D014155	Transcobalamins	A group of carrier proteins which bind with VITAMIN B12 in the BLOOD and aid in its transport. Transcobalamin I migrates electrophoretically as a beta-globulin, while transcobalamins II and III migrate as alpha-globulins.	Cobalamin-Binding Protein,Transcobalamin,Transcobalamin II,Vitamin B 12-Binding Protein,Vitamin B 12-Binding Proteins,Vitamin B12-Binding Protein,Cobalamin-Binding Proteins,Cobalophilin,Haptocorrin,Holo-Transcobalamin II,R-Binder,Transcobalamin (I),Transcobalamin I,Transcobalamin III,Vitamin B 12 Binder,Vitamin B12-Binding Proteins,B12-Binding Protein, Vitamin,Cobalamin Binding Protein,Cobalamin Binding Proteins,Holo Transcobalamin II,Protein, Cobalamin-Binding,Protein, Vitamin B12-Binding,Proteins, Cobalamin-Binding,Proteins, Vitamin B12-Binding,R Binder,Vitamin B 12 Binding Protein,Vitamin B 12 Binding Proteins,Vitamin B12 Binding Protein,Vitamin B12 Binding Proteins