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The prolactin (PRL) response to repeated injections of sulpiride, a dopamine antagonist, was evaluated in 18 healthy young men. Each subject received one or two injections of sulpiride 1 mg/kg i.m. The first injection was always given at 9 a.m. and the second after 2, 8, 24 or 48 h. Blood samples were taken through an indwelling venous catheter every 20 min during the first hour following the injection and then hourly for 12 h. The first sulpiride injection increased serum PRL level 10-fold the peak being reached after 20 or 40 min. The second injection up to 24 h had no effect on serum PRL, but when two sulpiride injections were given at a 48 h-interval, both caused a sharp increase in PRL. To conclude, PRL cells in man, after a sulpiride injection, may therefore be unresponsive to a second sulpiride injection for more than 24 h.
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
April 1987,
Journal of endocrinological investigation,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
January 1984,
European journal of clinical pharmacology,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
August 1981,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
January 1979,
Journal of neural transmission,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
January 1980,
Advances in biochemical psychopharmacology,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
November 1987,
Psychiatry research,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
May 1980,
Acta endocrinologica,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
August 1987,
British journal of clinical pharmacology,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
October 1980,
Il Farmaco; edizione pratica,
H Cohen, and
M Pugeat, and
J Tourniaire, and
J Bertrand
September 1975,
Horumon to rinsho. Clinical endocrinology,
