Biomaterial Database

1976 Hanford americium exposure incident: urinary excretion of trace metals during DTPA treatments. 1983

D R Kalkwarf, and V W Thomas, and K K Nielson, and M L Mauch

Urine samples from a person treated intravenously with diethyl-enetriaminepentaacetate (DTPA) salts for 3 yr to promote the excretion of 241Am were assayed for 24 elements including almost all of the trace metals currently recognized as essential for good health. Zinc was found to be the only metal excreted more rapidly than normal. An 18-mg urinary loss of body zinc was found to be associated with each 1-g injection of Na3CaDTPA. Use of either Na3ZnDTPA or Na3CaDTPA combined with oral dosages of ZnSO4 appeared to completely compensate for this loss, and it is unlikely that the patient experienced any zinc deficiency due to the DTPA treatment.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009688	Nuclear Reactors	Devices containing fissionable material in sufficient quantity and so arranged as to be capable of maintaining a controlled, self-sustaining NUCLEAR FISSION chain reaction. They are also known as atomic piles, atomic reactors, fission reactors, and nuclear piles, although such names are deprecated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Nuclear Reactor,Reactor, Nuclear,Reactors, Nuclear
D011832	Radiation Injuries	Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.	Radiation Sickness,Radiation Syndrome,Injuries, Radiation,Injury, Radiation,Radiation Injury,Radiation Sicknesses,Radiation Syndromes,Sickness, Radiation,Sicknesses, Radiation,Syndrome, Radiation,Syndromes, Radiation
D001753	Blast Injuries	Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)	Injuries, Blast,Blast Injury,Injury, Blast
D002057	Burns, Chemical	Burns caused by contact with or exposure to CAUSTICS or strong ACIDS.	Chemical Burns,Burn, Chemical,Chemical Burn
D004369	Pentetic Acid	An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	DTPA,Diethylenetriamine Pentaacetic Acid,Pentetates,Penthanil,Ca-DTPA,CaDTPA,CaNa-DTPA,Calcium Trisodium Pentetate,DETAPAC,Indium-DTPA,Mn-Dtpa,Pentacin,Pentacine,Pentaind,Pentetate Calcium Trisodium,Pentetate Zinc Trisodium,Sn-DTPA,Zinc-DTPA,Indium DTPA,Pentaacetic Acid, Diethylenetriamine,Pentetate, Calcium Trisodium,Zinc DTPA
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000062	Accidents, Occupational	Unforeseen occurrences, especially injuries in the course of work-related activities.	Accidents, Industrial,Industrial Accidents,Occupational Accidents,Accident, Industrial,Accident, Occupational,Industrial Accident,Occupational Accident
D000576	Americium	A completely man-made radioactive actinide with atomic symbol Am, and atomic number 95. Its valence can range from +3 to +6. Because of its nonmagnetic ground state, it is an excellent superconductor. It is also used in bone mineral analysis and as a radiation source for radiotherapy.