Biomaterial Database

Angiographic features of carcinoid heart disease. 1978

R G Holt, and R Gross, and E Carlsson

Cineangiocardiograms from 2 patients with carcinoid syndrome and cardiac involvement were reviewed. Gross and microscopic pathology specimens were available for 1 case. Both patients exhibited tricuspid valvar stenosis and insufficiency. The area of the pulmonic valve was similar in both with narrowing of the annulus and tapering toward the valve of the proximal pulmonary artery and the subvalvar right ventricular outflow tract, producing an hourglass appearance, which the authors feel is characteristic of this disease.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008303	Malignant Carcinoid Syndrome	A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)	Carcinoid Syndrome, Malignant,Carcinoid Syndromes, Malignant,Malignant Carcinoid Syndromes,Syndrome, Malignant Carcinoid,Syndromes, Malignant Carcinoid
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011664	Pulmonary Valve	A valve situated at the entrance to the pulmonary trunk from the right ventricle.	Pulmonary Valves,Valve, Pulmonary,Valves, Pulmonary
D002275	Carcinoid Heart Disease	Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.	Carcinoid Heart Diseases,Heart Disease, Carcinoid,Heart Diseases, Carcinoid
D002932	Cineangiography	Motion pictures of the passage of contrast medium through blood vessels.	Cineangiographies
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000790	Angiocardiography	Radiography of the heart and great vessels after injection of a contrast medium.	Angiocardiographies
D014261	Tricuspid Valve	The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.	Tricuspid Valves,Valve, Tricuspid,Valves, Tricuspid