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Isolated rat hearts were perfused by the Langendorff procedure to study the metabolic effects of ethanol, acetaldehyde and acetate on the myocardium. Ethanol caused a slight decrease in the work output of the heart and concomitant changes in the oxygen consumption and cellular redox state. A low-Km (1 microM) acetaldehyde dehydrogenase activity was found in rat heart mitochondria, but an acetaldehyde concentration of 50 microM or higher was necessary to reduce tissue NAD+ in the isolated perfused heart. One hundred microM or higher concentrations of acetaldehyde caused an increase in the work output of the heart, with a concomitant oxidation of NADH. Acetaldehyde at a 50 microM concentration did not affect myocardial lipid metabolism. Acetate caused a reduction of mitochondrial NAD+, an increase in the coronary flow and an increase in the O2 consumption of the perfused heart. Practically all of the oxygen consumption could be accounted for by acetate oxidation. A 2 mM concentration of acetate inhibited the oxidation of oleate by 35% and stimulated oleate incorporation into myocardial lipids by 90%; therefore, it appears that the acute metabolic derangements of the heart muscle during ethanol metabolism in vivo are probably mainly caused by acetate.
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
March 1961,
Endocrinology,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
January 1974,
International journal of neurology,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
January 1956,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
January 1975,
Annual review of medicine,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
January 1956,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
January 1981,
Pharmacology & therapeutics,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
November 1972,
Journal of neurochemistry,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
November 1969,
The Medical clinics of North America,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
December 1992,
Biochimica et biophysica acta,
K J Peuhkurinen, and
K T Kiviluoma, and
J K Hiltunen, and
T E Takala, and
I E Hassinen
November 1983,
Biochemical pharmacology,
