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The purpose of this trial was to minimize local inflammation caused by intravesical instillation of antitumor agents, especially Adriamycin, in the treatment of bladder tumor. Tranexamic acid was chosen as the solvent vehicle for Adriamycin and IV bolus injection of an antiallergic drug, Stronger neo-minophagen C, was given at the time of each instillation. Of 81 cases scheduled for Adriamycin instillation therapy, nine cases (11.1%) dropped out due to severe bladder inflammation, while 17 other cases (21%) experienced local side-effects which were tolerated. Of 62 evaluable cases in whom more than eight instillations were performed, complete regression was observed in six cases (9.7%) and partial regression in 20 cases (32.3%).
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C Y Fai, and
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N Sakamoto, and
S Nagata
January 1992,
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T Kakinoki, and
M Kawahara, and
S Asechi, and
N Sakamoto, and
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N Sakamoto, and
S Nagata
January 1984,
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Y Ohi, and
K Okamoto, and
T Kawabata, and
A Hanafusa, and
C Y Fai, and
T Kakinoki, and
M Kawahara, and
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March 1984,
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Y Ohi, and
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C Y Fai, and
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N Sakamoto, and
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December 2014,
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S Nagata
April 1998,
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June 1983,
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April 1979,
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January 1982,
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