-transparent.png){kind=logo}
The effect of poly(ADP-ribose) synthesis on chromatin structure was investigated by velocity sedimentation and electron microscopy. We demonstrate that locally relaxed regions can be generated within polynucleosome chains by the activity of their intrinsic poly(ADP-ribose)polymerase. This relaxation phenomenon is also shown to be NAD dependent and to be correlated with the formation of hyper(ADP-ribosyl)ated forms of histone H1. Evidence is also presented which suggests that hyper(ADP-ribosyl)ated histone H1 is neither released from the relaxed chromatin, nor does it seem to participate in polynucleosomal aggregation.
Related Publications
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
December 1982,
Canadian journal of biochemistry,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
January 1984,
Methods in enzymology,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
January 1985,
European journal of biochemistry,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
June 1982,
Proceedings of the National Academy of Sciences of the United States of America,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
May 1989,
The Journal of biological chemistry,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
July 1985,
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
April 1996,
The Journal of biological chemistry,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
January 1989,
Cytobios,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
January 2016,
The Journal of biological chemistry,
R J Aubin, and
A Fréchette, and
G de Murcia, and
P Mandel, and
A Lord, and
G Grondin, and
G G Poirier
January 2015,
PloS one,
