Radioassay problems associated with the clinical use of a 82Rb radionuclide generator. 1983

S L Waters, and K R Butler, and J C Clark, and P L Horlock, and M J Kensett, and I W Goodier, and J Makepeace, and D Smith, and M J Woods, and J W Barnes

The short-lived positron emitting radionuclide 82Rb (t1/2 1.27 min) is conveniently available from a 82Sr/82Rb generator system. The parent nuclide (t1/2 25.5d) produced from the spallation of molybdenum, has associated with it varying quantities of other long-lived strontium radionuclides, namely 85Sr, 89Sr and 90Sr. It is important therefore in the clinical use of such material that the levels of strontium radionuclides being administered to patients is carefully assayed and controlled. The problems associated with these measurements are discussed with special reference to the radiation dose received by the patient and the problems in resolving overlapping peaks with different FWHMs.

UI MeSH Term Description Entries
D011829 Radiation Dosage The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv). Sievert Units,Dosage, Radiation,Gray Units,Gy Radiation,Sv Radiation Dose Equivalent,Dosages, Radiation,Radiation Dosages,Units, Gray,Units, Sievert
D011868 Radioisotopes Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Daughter Isotope,Daughter Nuclide,Radioactive Isotope,Radioactive Isotopes,Radiogenic Isotope,Radioisotope,Radionuclide,Radionuclides,Daughter Nuclides,Daugter Isotopes,Radiogenic Isotopes,Isotope, Daughter,Isotope, Radioactive,Isotope, Radiogenic,Isotopes, Daugter,Isotopes, Radioactive,Isotopes, Radiogenic,Nuclide, Daughter,Nuclides, Daughter
D011876 Radionuclide Generators Separation systems containing a relatively long-lived parent radionuclide which produces a short-lived daughter in its decay scheme. The daughter can be periodically extracted (milked) by means of an appropriate eluting agent. Radioisotope Generators,Generator, Radioisotope,Generator, Radionuclide,Generators, Radioisotope,Generators, Radionuclide,Radioisotope Generator,Radionuclide Generator
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012413 Rubidium An element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells.
D013326 Strontium Radioisotopes Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes. Radioisotopes, Strontium

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