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Synthetic esters of the C-4 hydroxyl group of podophyllotoxin (I) were prepared. In addition, esters were synthesized using the diol system of tetrahydropyranyl podophyllol (XV), produced by reducing the lactone ring of tetrahydropyranyl podophyllotoxin with lithium aluminum hydride. Six compounds, the acrylate (IV), 3,3-dimethyl acrylate (V), phenoxyacetate (IX), and ethyl adipate (XI) of I as well as podophyllol (XIV) and tetrahydropyranyl podophyllol dimesylate (XVIII), showed significant activity when tested using the P-388 lymphocytic leukemia screen at 3 mg/kg/day. None of the esters showed higher activity than that shown by the parent molecule I when tested at the same dosage level.
R K Levy, and
I H Hall, and
K H Lee
July 2018,
European journal of medicinal chemistry,
R K Levy, and
I H Hall, and
K H Lee
January 2019,
Frontiers in chemistry,
R K Levy, and
I H Hall, and
K H Lee
October 2014,
European journal of medicinal chemistry,
R K Levy, and
I H Hall, and
K H Lee
January 2014,
Journal of Asian natural products research,
R K Levy, and
I H Hall, and
K H Lee
September 2011,
European journal of medicinal chemistry,
R K Levy, and
I H Hall, and
K H Lee
December 2020,
Bioorganic & medicinal chemistry,
R K Levy, and
I H Hall, and
K H Lee
January 2012,
Archiv der Pharmazie,
R K Levy, and
I H Hall, and
K H Lee
December 2024,
Pharmaceutical biology,
R K Levy, and
I H Hall, and
K H Lee
November 2019,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
R K Levy, and
I H Hall, and
K H Lee
April 2001,
European journal of medicinal chemistry,
