Biomaterial Database

[Effect of thyroid inhibitors and thyroidectomy on sialic acid content of rat blood and liver]. 1978

N I Kuz'mak

Effect of experimental hypothyreosis, caused by various thyrostatic agents, on content of sialic acids was studied in blood plasma and liver tissue of white rat males. In hypothyreosis content of sialic acids was distinctly increased in blood serum but decreased in homogenate and structure elements of liver tissue. Alteration in content of sialic in blood plasma correlated with their content in liver structure elements. Content of sialic acids in blood plasma and liver tissue was shown to depend on dosage and length of administration of various thyrostatic preparations. Mechanism of increase in concentration of sialic acids in blood serum under influence of experimental hypothyreosis is discussed.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008779	Methylthiouracil	A thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. It is used in the treatment of hyperthyroidism.	4-Methyl-2-thiouracil,Alkiron,Metacil,Thimecil
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012794	Sialic Acids	A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.	N-Acetylneuraminic Acids,Acids, N-Acetylneuraminic,Acids, Sialic,N Acetylneuraminic Acids
D013961	Thyroid Gland	A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.	Thyroid,Gland, Thyroid,Glands, Thyroid,Thyroid Glands,Thyroids
D013965	Thyroidectomy	Surgical removal of the thyroid gland. (Dorland, 28th ed)	Thyroidectomies
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus