-transparent.png){kind=logo}
The effects of 14 daily injections of tripelennamine on several dependent measures were determined in groups of rats that received 0.0 (vehicle only), 2.0, 4.0, 8,0, or 16.0 mg/kg of the drug.l Tripelennamine did not affect body weights, organ weights (heart, liver, adrenals, kidneys), or blood glucose levels. Daily water intake was, however, directly and significantly related to tripelennamine dose. The drug failed to influence performance in a grasping response assay, or locomotion as measured in running wheels when rats received footshocks immediately before assessment of locomotion. Tripelennamine did significantly reduce locomotion when rats were not shocked before testing. Nociception, as measured via a hot-plate assay, also was altered by the drug. Here, rats exposed to 16 mg/kg evinced paw-lick latencies far greater than those that received lower doses. These results indicate that tripelennamine produced observable behavioral effects at doses which are not obviously toxic.
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
June 1981,
Laboratory animal science,
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
January 1974,
Zeitschrift fur Versuchstierkunde,
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
December 2008,
Cell biochemistry and function,
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
January 1953,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
June 2006,
Archives of animal nutrition,
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
January 1981,
Toxicology,
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
October 1956,
The Journal of nutrition,
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
September 1968,
Growth,
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
September 1966,
Growth,
K P Nanry, and
R G Sewell, and
J A Gallus, and
S A Vanecek, and
A Poling
September 1967,
Growth,
