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A new benzimidazole anthelmintic, triclabendazole (CGA-89317) was found to be highly efficient against mature and early immature Fasciola hepatica infections in sheep. At the dose rate of 2.5 mg/kg the efficiency was 90 and 98 per cent against flukes aged eight and 12 weeks respectively. At 5 mg/kg the drug was 92 and 98 per cent efficient against flukes aged four and eight weeks respectively and 100 per cent against 12-week-old flukes. An efficiency of 93 and 98 per cent was achieved against one-week-old flukes and 99 to 100 per cent against flukes aged two to four weeks at 10 mg/kg. At this dose rate the drug had 100 per cent efficiency against six-week-old flukes. If the dose was increased to 15 mg/kg, 98 per cent efficiency was achieved one day after infection. Triclabendazole was equally efficient when administered orally or by intraruminal or intra-abomasal injection. The maximum tolerated dose of 200 mg/kg was established.
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
November 1983,
Australian veterinary journal,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
February 1968,
Australian veterinary journal,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
January 1984,
The Veterinary record,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
March 1969,
Australian veterinary journal,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
September 1983,
Veterinary parasitology,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
January 1988,
The Veterinary record,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
September 1988,
The Veterinary record,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
May 1987,
The Veterinary record,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
February 1987,
Experimental parasitology,
J C Boray, and
P D Crowfoot, and
M B Strong, and
J R Allison, and
M Schellenbaum, and
M Von Orelli, and
G Sarasin
May 1969,
American journal of veterinary research,
