Biomaterial Database

[High-density lipoprotein cholesterol and the atherogenic index in patients with different types of hyperlipoproteinemias]. 1983

I Apostolov, and R Naumova, and L Balabanski, and I Goranov

A total of 180 subjects (82 males and 98 females), aged from 20 to 60 were examined. Sixty four of them (29 males and 35 females) were regular blood donors (control group) and 116 subjects (53 males and 63 females) - with huperlipoproteinemias: type IIa - 50 subjects (17 males and 33 females), type IIb - 37 (23 males and 14 females) and type IV - 29 (13 males and 16 females). Triglycerides, total cholesterol and cholesterol in lipoproteins with high density (Ch-HDLP) were also determined. The percentage of Ch-HDLP was calculated from total cholesterol (TCh) as well as the atherogenic index [(TCh-Ch-HDLP): Ch-KDLP)] A drop down of Ch-HDLP (p less than 0,01) was found only in hyperlipoproteinemia type IV, as compared with the control group. Ch-HDLP percentage was diminished (p less than 0,001) whereas the atherogenic index was increased (p less than 0,001) in hyperlipoproteinemias from the three types. Both sexes were affected by the changes decrided.

UI	MeSH Term	Description	Entries
D006951	Hyperlipoproteinemias	Conditions with abnormally elevated levels of LIPOPROTEINS in the blood. They may be inherited, acquired, primary, or secondary. Hyperlipoproteinemias are classified according to the pattern of lipoproteins on electrophoresis or ultracentrifugation.	Hyperlipoproteinemia
D008075	Lipoproteins, HDL	A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.	High Density Lipoprotein,High-Density Lipoprotein,High-Density Lipoproteins,alpha-Lipoprotein,alpha-Lipoproteins,Heavy Lipoproteins,alpha-1 Lipoprotein,Density Lipoprotein, High,HDL Lipoproteins,High Density Lipoproteins,Lipoprotein, High Density,Lipoprotein, High-Density,Lipoproteins, Heavy,Lipoproteins, High-Density,alpha Lipoprotein,alpha Lipoproteins
D008076	Cholesterol, HDL	Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.	High Density Lipoprotein Cholesterol,Cholesterol, HDL2,Cholesterol, HDL3,HDL Cholesterol,HDL(2) Cholesterol,HDL(3) Cholesterol,HDL2 Cholesterol,HDL3 Cholesterol,alpha-Lipoprotein Cholesterol,Cholesterol, alpha-Lipoprotein,alpha Lipoprotein Cholesterol
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001782	Blood Donors	Individuals supplying blood or blood components for transfer to histocompatible recipients.	Blood Donor,Donor, Blood,Donors, Blood
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man