Biomaterial Database

Ontogenesis of the myenteric plexus in the cat gastrointestinal sphincters. III. Synaptogenesis. 1983

I Lolova

Synaptogenesis in the cat myenteric ganglia of the lower esophageal, pyloric and ileocecal sphincters in the fetal life and at different postnatal stages of development was examined. The synaptic formation began in the early fetal period. The first immature synapses were of axosomatic and axodendritic types. The new formation and maturation of the synaptic contacts was an active process in the fetal period and in the first postnatal weeks, but it continued to the adult level. It was expressed quantitatively in the increase of the surface area of the synaptic contact zones, the number of the synapses, the length of the synaptic contact zones and the number of the synaptic vesicles. Fine structural features of the synaptic maturation were the increased pleomorphism of the synaptic vesicles, widing and lengthening of the thickening of the opposed membranes, the appearance of the coated evaginations and vesicles. Synaptic morphology became more complex because of the including of different in size and structure pre- and postsynaptic components. The frequency of the synapses on dendritic spines and synapses "en passant" increased. The synaptogenesis in the three sphincters studied exhibited a different dynamics. The parallel advance in the neuronal and synaptic differentiation and the relationship between the desmosomal junctions and synapses were discussed.

UI	MeSH Term	Description	Entries
D009197	Myenteric Plexus	One of two ganglionated neural networks which together form the ENTERIC NERVOUS SYSTEM. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility. (From FASEB J 1989;3:127-38)	Auerbach's Plexus,Auerbach Plexus,Auerbachs Plexus,Plexus, Auerbach's,Plexus, Myenteric
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004064	Digestive System	A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).	Ailmentary System,Alimentary System
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013569	Synapses	Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.	Synapse