Biomaterial Database

On the validity of the NSD concept. 1983

P Brumm

The nominal standard dose depends mainly upon the skin reaction, the field size, and the location. In particular, different degrees of skin reaction cause variations in the "tolerance dose" up to a factor of 2. The influence of these parameters must be taken into account carefully in order to attain valid conclusions. The NSD concept has been verified by re-evaluation of Strandqvist's investigation. An exponent of 0.28 +/- 0.04 has been calculated, which is at the lower limit of Ellis' value (0.35). The use of the NSD formula may fail for radiation regimens which are not bound to skin reaction. Several radiation schemes in the treatment of lung cancer exhibit worse tumour control though NSD values are higher. For this a strong correlation between survival rate and fractionation frequency has been found.

UI	MeSH Term	Description	Entries
D008175	Lung Neoplasms	Tumors or cancer of the LUNG.	Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D011836	Radiation Tolerance	The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.	Radiation Sensitivity,Radiosensitivity,Sensitivity, Radiation,Tolerance, Radiation,Radiation Sensitivities,Radiation Tolerances,Radiosensitivities,Sensitivities, Radiation,Tolerances, Radiation
D011879	Radiotherapy Dosage	The total amount of radiation absorbed by tissues as a result of radiotherapy.	Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor