-transparent.png){kind=logo}
The effect of profound hypercapnia on acute hypoxic respiratory failure is evaluated. Eight dogs were subjected to oleic acid-induced acute respiratory failure. Four dogs were ventilated normally, and four dogs were made hypercapneic by rebreathing exhaled CO2. In the hypercapneic animals, heart rate and alveolar-arterial oxygen difference were significantly lower than in normocapneic animals, while mixed venous O2 cardiac index, oxygen delivery index, stroke volume index, and left ventricular stroke work were significantly higher. Mean arterial pressure was maintained at preinjury levels. Pulmonary and systemic vascular resistance increased in both experimental groups. There was no significant difference between groups for gravimetric determination of lung water. Cardiopulmonary performance in acute respiratory failure is improved with hypercapnia. This may be related to CO2-induced catecholamine release.
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
September 1994,
JAMA,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
July 2019,
Intensive care medicine experimental,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
September 2005,
Chest,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
September 2014,
BMJ case reports,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
August 2017,
Thorax,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
May 1985,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
January 2003,
Respiration; international review of thoracic diseases,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
January 1999,
British medical bulletin,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
May 1986,
Chest,
G J Slotman, and
G W Machiedo, and
R T Novak, and
B F Rush
January 1973,
Fiziolohichnyi zhurnal,
