-transparent.png){kind=logo}
The possibility that the radiosensitivity of lymphoblastoid cell lines from patients with ataxia telangiectasia (A-T) is due to an aberrant content of histones has been examined. The histone pattern of lymphoblastoid cell lines derived from A-T patients was found to be indistinguishable from that obtained from normal individuals. X-ray irradiation led to a greater decrease in cell growth rate in the A-T cells than in the normal cells but was accompanied by a greater decrease of DNA synthesis rate in the normal cells. This difference in radiosensitivity was not reflected in differences in the content or rates of synthesis of histones or of major non-histone proteins in these cells. Reduction in the rate of DNA synthesis was not associated with the appearance of the lysine-rich histone variant H1. We conclude that the hypersensitivity to ionizing radiation in A-T cells is not due to fundamental differences in the composition or synthesis of the major chromosomal proteins.
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
December 1982,
Radiation research,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
August 1980,
Nucleic acids research,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
March 1986,
Mutation research,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
March 1983,
Biochemistry international,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
October 1989,
Mutation research,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
June 1998,
Mutation research,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
January 1987,
Molecular and cellular biochemistry,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
January 1992,
Molecular carcinogenesis,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
January 1982,
Environmental mutagenesis,
K H Kraemer, and
N Soares, and
H L Waters, and
M Bustin
January 1981,
Mutation research,
