Dominant lethal effects of n-butyl glycidyl ether in mice. 1983

E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse

Using the dominant lethal assay, the ability of n-butyl glycidyl ether to induce mutations in male mice was investigated. No significant dose-related changes either in pregnancy rates or in average number of implants per pregnant female were found. However, while the results were not altogether conclusive, there was evidence of a significant increase in fetal death rates by the end of the first week after the highest dosage was administered.

UI MeSH Term Description Entries
D008297 Male Males
D008815 Mice, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation. Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D010064 Embryo Implantation Endometrial implantation of EMBRYO, MAMMALIAN at the BLASTOCYST stage. Blastocyst Implantation,Decidual Cell Reaction,Implantation, Blastocyst,Nidation,Ovum Implantation,Blastocyst Implantations,Decidual Cell Reactions,Embryo Implantations,Implantation, Embryo,Implantation, Ovum,Implantations, Blastocyst,Implantations, Embryo,Implantations, Ovum,Nidations,Ovum Implantations
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011270 Pregnancy, Animal The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH. Animal Pregnancies,Animal Pregnancy,Pregnancies, Animal
D004852 Epoxy Compounds Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS. Epoxide,Epoxides,Epoxy Compound,Oxiranes,Compound, Epoxy,Compounds, Epoxy
D004988 Ethers, Cyclic Compounds of the general formula R-O-R arranged in a ring or crown formation. Cyclic Ether,Cyclic Ethers,Ether, Cyclic
D005260 Female Females

Related Publications

E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
October 1979, The Journal of the Society of Occupational Medicine,
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
December 2007, Drug metabolism and disposition: the biological fate of chemicals,
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
July 1985, Xenobiotica; the fate of foreign compounds in biological systems,
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
October 2021, International journal of biological macromolecules,
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
January 1988, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
June 1990, Mutation research,
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
January 1986, Mutation research,
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
December 1992, Mutation research,
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
January 1999, IARC monographs on the evaluation of carcinogenic risks to humans,
E B Whorton, and T G Pullin, and A F Frost, and A Onofre, and M S Legator, and D S Folse
December 1987, Toxicology letters,
Copied contents to your clipboard!