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The phototoxicity and mutagenicity of 4,5'-dimethylangelicin (Ang) were assessed in cultures of hamster cells and human skin fibroblasts after long-wave ultraviolet irradiation. To obtain an impression of the clinical usefulness of Ang, we compared the phototoxicity and mutagenicity of this compound with those of 8-methoxypsoralen (8-MOP). To reach the same cell-killing rate in hamster cells and human skin fibroblasts, the concentration of Ang had to be 15 times higher than that of 8-MOP at comparable doses of radiation. Whether we used the same concentrations and an adjusted radiation dose or adjusted concentrations of Ang and 8-MOP at a constant radiation dose, the mutation induction in hamster cells and human skin fibroblasts was much higher after incubation with Ang than with 8-MOP.
R N Swart, and
M A Beckers, and
A A Schothorst
December 1979,
Mutation research,
R N Swart, and
M A Beckers, and
A A Schothorst
May 1979,
Mutation research,
R N Swart, and
M A Beckers, and
A A Schothorst
January 1977,
Genetika,
R N Swart, and
M A Beckers, and
A A Schothorst
July 1973,
Radiation research,
R N Swart, and
M A Beckers, and
A A Schothorst
January 1986,
Acta dermato-venereologica. Supplementum,
R N Swart, and
M A Beckers, and
A A Schothorst
February 1973,
Mutation research,
R N Swart, and
M A Beckers, and
A A Schothorst
October 1977,
The Journal of investigative dermatology,
R N Swart, and
M A Beckers, and
A A Schothorst
March 1982,
Mutation research,
R N Swart, and
M A Beckers, and
A A Schothorst
November 1982,
Mutation research,
R N Swart, and
M A Beckers, and
A A Schothorst
June 1983,
Gan,
