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The percutaneous absorption of 3H-promestriene (an antiseborrhoeic agent; 3-propoxy-17 beta-methoxy-1,3,5(10)-estratriene) was studied in rats and human subjects. Extensive and continual absorption of the tritium label (about 50% dose in 3 days) occurred in rats when the treated area of skin (ca. 30 micrograms/cm2) was occluded; when unabsorbed material was washed off after 6 h, a substantial proportion of the applied 3H (about 25% dose) had been absorbed to be excreted later. In contrast, less than 1% of the 3H applied to the skin of human volunteers (0.1-0.5 mg/cm2) was absorbed within 6 h and subsequently excreted. In rats, tissue concentrations of 3H were greatest in the liver, adrenals and ovaries.
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
October 1971,
Justus Liebigs Annalen der Chemie,
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
December 1970,
Steroids,
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
March 1965,
Life sciences (1962),
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
August 1999,
Journal of medicinal chemistry,
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
January 1968,
Steroids,
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
February 1966,
Annales pharmaceutiques francaises,
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
November 1974,
Steroids,
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
November 1970,
Steroids,
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
February 2002,
Acta crystallographica. Section C, Crystal structure communications,
D H Moore, and
L F Chasseaud, and
A Darragh, and
T Taylor, and
D G Cresswell
January 1954,
Il Farmaco; edizione scientifica,
