Biomaterial Database

[The spirochetal etiology of erythema chronicum migrans and of meningo-polyneuritis Garin-Bujadoux-Bannwarth]. 1983

R Ackermann

Erythema chronicum migrans and tick-borne meningo-polyneuritis Garin-Bujadoux-Bannwarth are caused by a spirochete transmitted by ixodes ricinus. The same is true for Lyme disease, which is the erythema chronicum migrans infection of North-America transmitted by ticks of the same genus. In Europe, this etiology is indicated by demonstration of IgG and IgM antibodies against borrelia duttoni during the course of infection and by immunofluorescence staining of spirochetes in ticks at sites of infection. In the USA, scientists succeeded in isolating from ticks as well as from blood, skin and cerebrospinal fluid of patients with Lyme disease. In addition patients showed antibodies against the isolated spirochete. The etiologic findings allow a better causative therapy as well as the investigation of pathogenesis and epidemiology of this multiform disease which may involve skin, nervous system, joints and heart.

UI	MeSH Term	Description	Entries
D011115	Polyneuropathies	Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.	Polyneuropathy, Acquired,Polyneuropathy, Critical Illness,Polyneuropathy, Familial,Polyneuropathy, Inherited,Polyneuropathy, Motor,Acquired Polyneuropathies,Acquired Polyneuropathy,Critical Illness Polyneuropathies,Critical Illness Polyneuropathy,Familial Polyneuropathies,Familial Polyneuropathy,Inherited Polyneuropathies,Inherited Polyneuropathy,Motor Polyneuropathies,Motor Polyneuropathy,Polyneuropathies, Acquired,Polyneuropathies, Critical Illness,Polyneuropathies, Familial,Polyneuropathies, Inherited,Polyneuropathies, Motor,Polyneuropathy
D001733	Bites and Stings	Injuries inflicted by the TEETH or poisoning caused by VENOMS of animals.	Stings,Bites,Stings and Bites,Bite,Sting
D001898	Borrelia	A genus of gram-negative, anaerobic, helical bacteria, various species of which produce RELAPSING FEVER in humans and other animals.
D002555	Cerebrospinal Fluid	A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.	Cerebro Spinal Fluid,Cerebro Spinal Fluids,Cerebrospinal Fluids,Fluid, Cerebro Spinal,Fluid, Cerebrospinal,Fluids, Cerebro Spinal,Fluids, Cerebrospinal,Spinal Fluid, Cerebro,Spinal Fluids, Cerebro
D003429	Cross Reactions	Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.	Cross Reaction,Reaction, Cross,Reactions, Cross
D004890	Erythema	Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	Erythemas
D005060	Europe	The continent north of AFRICA, west of ASIA and east of the ATLANTIC OCEAN.	Northern Europe,Southern Europe,Western Europe
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000907	Antibodies, Bacterial	Immunoglobulins produced in a response to BACTERIAL ANTIGENS.	Bacterial Antibodies
D013142	Spirochaeta	A genus of flexible, spiral rods found in hydrogen sulfide-containing mud, sewage, and polluted water. None of the species properly referred to in this genus are pathogenic.

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