-transparent.png){kind=logo}
Alkylating activity of cytostatic drugs was studied in relation to their mutagenicity and toxicity in E. coli WP2 uvrA. Four classes of directly acting cytostatic drugs were studied: nitrogen mustards (nitrogen mustard, melphalan, chlorambucil and phosphoramide mustard, a metabolite of cyclophosphamide), ethyleneimine derivatives (Thio-TEPA, TEPA and triethylenemelamine), busulfan, and halogenated nitrosoureas. The reference compounds included methyl methanesulfonate, ethyleneimine and methylnitrosourea. Guanosine alkylation was determined by fluorometry. The rate of guanosine and nitrobenzylpyridine alkylation agreed well. Nitrogen mustard derivatives and triethylenemelamine were the most potent alkylating agents among the cytostatic drugs; nitrogen mustard was 5 to 10 times more active than methyl methanesulfonate. Ethyleneimine derivatives, busulfan and the nitrosoureas were relatively weak alkylating agents. Nitrogen mustard and triethylenemelamine were the most potent mutagens to bacteria; they were also among the most toxic drugs studied.
K Hemminki, and
S Kallama, and
K Falck
January 1989,
Medizinische Monatsschrift fur Pharmazeuten,
K Hemminki, and
S Kallama, and
K Falck
January 1986,
IARC scientific publications,
K Hemminki, and
S Kallama, and
K Falck
June 1979,
Lancet (London, England),
K Hemminki, and
S Kallama, and
K Falck
January 1983,
Annals of the New York Academy of Sciences,
K Hemminki, and
S Kallama, and
K Falck
January 1986,
IARC scientific publications,
K Hemminki, and
S Kallama, and
K Falck
January 1984,
Bollettino dell'Istituto sieroterapico milanese,
K Hemminki, and
S Kallama, and
K Falck
January 1993,
Wiener medizinische Wochenschrift (1946),
K Hemminki, and
S Kallama, and
K Falck
January 1995,
Folia microbiologica,
K Hemminki, and
S Kallama, and
K Falck
January 1982,
International archives of occupational and environmental health,
