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Nuclear incorporation of 3 H-Thymidine is widely used as a measure of DNA synthesis and cell proliferation. We have studied by this way the growth-stimulating action of estrogens on a human breast cancer cell line (FAM). We have observed discrepancies between 3 H-Thymidine incorporation and true cell proliferation: after estradiol treatment, we have noted increased incorporation of DNA precursor but no change in the cell number. Our preliminary results show that there was no increase of the size of nuclei, no increase of the DNA content. So, there is a need for a cell number control of results recording a growth promoting activity when only based on 3 H-Thymidine incorporation. A biochemical explanation of this discrepancy is submitted.
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
August 1997,
International journal of oncology,
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
January 1974,
Planta,
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
August 1979,
The Journal of clinical endocrinology and metabolism,
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
July 1972,
Annales de l'Institut Pasteur,
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
May 1991,
Calcified tissue international,
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
January 1971,
Folia biologica,
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
July 1977,
Radioisotopes,
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
January 1972,
Photochemistry and photobiology,
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
December 1961,
Science (New York, N.Y.),
S Jozan, and
A Mirouze, and
A G Gay, and
B Marques, and
J F David
January 1972,
Beitrage zur Pathologie,
