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A new method was developed to permit the contact of haptens exclusively with the vaginal mucosal surfaces of the guinea pig. The method described has some unique characteristics that make it potentially useful, not only for studies of the immune response but also for other areas of toxicologic concern. Utilizing this approach it was demonstrated that delayed contact hypersensitivity was as readily produced in the vagina as it was in the skin. Grossly, the vaginas of sensitized animals appeared normal when challenged with a non-irritating concentration of hapten but, histologically, a perivascular lymphocytic cuffing, that is the hallmark of the delayed hypersensitivity response, was demonstrated.
E A Newmann, and
E V Buehler, and
R D Parker
February 1965,
Archives of dermatology,
E A Newmann, and
E V Buehler, and
R D Parker
August 1969,
British journal of experimental pathology,
E A Newmann, and
E V Buehler, and
R D Parker
October 1966,
Journal of immunology (Baltimore, Md. : 1950),
E A Newmann, and
E V Buehler, and
R D Parker
February 1975,
Journal of periodontology,
E A Newmann, and
E V Buehler, and
R D Parker
May 1982,
Contact dermatitis,
E A Newmann, and
E V Buehler, and
R D Parker
May 1969,
Annales de l'Institut Pasteur,
E A Newmann, and
E V Buehler, and
R D Parker
July 1982,
Contact dermatitis,
E A Newmann, and
E V Buehler, and
R D Parker
January 1965,
Nature,
E A Newmann, and
E V Buehler, and
R D Parker
February 1966,
Immunology,
E A Newmann, and
E V Buehler, and
R D Parker
April 1992,
Inflammation,
