Biomaterial Database

Metabolic changes in skeletal muscle following high-energy trauma. 1983

A Holmström, and J Larsson, and D H Lewis

Changes in energy metabolism in skeletal muscle tissue after high-energy trauma were studied. Trauma was inflicted to the thigh of anaesthetized pigs with a high-velocity missile. The changes in contents of adenine nucleotides, phosphoryl creatine, creatine, lactate and glycogen were studied within areas of discoloured muscle tissue nearest the wound and were compared with corresponding values in adjacent normally coloured muscle. Severe and presumably irreversible changes in energy metabolism were found in discoloured muscle, with depletion of ATP and phosphoryl creatine and marked increase in lactate levels. No such changes were found in the normally coloured tissue. The progression of the changes during a 10-hour observation period and the magnitude of the metabolic disturbance indicate that such discoloured muscle tissue must be regarded as non-viable. Discolouration can therefore be regarded as a useful clinical sign during debridement of traumatized muscle tissue.

UI	MeSH Term	Description	Entries
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D004734	Energy Metabolism	The chemical reactions involved in the production and utilization of various forms of energy in cells.	Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D006614	Hindlimb	Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)	Hindlimbs
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D014948	Wounds, Gunshot	Disruption of structural continuity of the body as a result of the discharge of firearms.	Gunshot Wound,Gunshot Wounds,Wound, Gunshot