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Cells from cultured human and murine myeloma cell lines and circulating leukaemic plasma cells from four patients with generalized myeloma were studied by transmission and scanning electron microscopy and time-lapse cinematography. Both circulating and cultured cells exhibited consistent surface architectures and varying numbers of prominent blebs of different sizes were seen, in addition to microvilli. The presence of surface blebs appears to be a characteristic feature for secreting and non-secreting myeloma cells.
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