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4,5' ,8-trimethylpsoralen photosensitizes the inhibition of the induction of nitrate reductase in XD cells of tobacco, by near ultraviolet light. The photosensitization depends on the concentration of 4,5' ,8-trimethylpsoralen and the near ultraviolet light dose. Concomitant with the inhibition of nitrate reductase induction there is a severe inhibition of DNA and RNA synthesis. Oxygen uptake and protein synthesis are not affected. Translation of preexisting mRNA coding for nitrate reductase is insesitive to 4,5' ,8-trimethylpsoralen and near ultraviolet light. It is concluded that the DNA of these cells is the target for the photochemical reaction of 4,5' ,8-trimethylpsoralen. The template activity of the DNA is inhibited, and the expression of the genome thereby prevented. Translation of preexisting nRNA is not affected.
Y M Heimer, and
E Ben-Hur, and
E Riklis
January 1980,
Archives of virology,
Y M Heimer, and
E Ben-Hur, and
E Riklis
January 1978,
Intervirology,
Y M Heimer, and
E Ben-Hur, and
E Riklis
January 1986,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans,
Y M Heimer, and
E Ben-Hur, and
E Riklis
February 1983,
Mutation research,
Y M Heimer, and
E Ben-Hur, and
E Riklis
December 1973,
Biochimica et biophysica acta,
Y M Heimer, and
E Ben-Hur, and
E Riklis
April 1987,
Biochemistry,
Y M Heimer, and
E Ben-Hur, and
E Riklis
May 1981,
The Journal of investigative dermatology,
Y M Heimer, and
E Ben-Hur, and
E Riklis
May 1988,
Journal of molecular biology,
Y M Heimer, and
E Ben-Hur, and
E Riklis
January 1975,
Dermatologica,
Y M Heimer, and
E Ben-Hur, and
E Riklis
October 1990,
Photochemistry and photobiology,
