-transparent.png){kind=logo}
The effects of regional lung differences in alveolar mechanics on the transpulmonary pressure-volume (Ptp-V) relationship and the single-breath washout (SBW) of nitrogen were investigated by mathematical modeling and postmorten human lung experiments. Regional nonuniformity in alveolar collapse and re-opening were associated with differences in gravitational stress or elasticity. Model simulations predict that neither type of regional nonuniformity qualitatively affects the shape of the Ptp-V curve, but does affect the terminal (or small-volume) portion of the SBW. Comparisons of characteristics of the Ptp-V and SBW curves indicate that regional nonuniformity in alveolar collapse is an important mechanism associated with ventilation inhomogeneity.
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
October 1989,
Journal of applied physiology (Bethesda, Md. : 1985),
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
January 1959,
Le Poumon et le coeur,
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
June 2010,
Veterinary research communications,
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
December 2015,
Anesthesiology,
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
May 1982,
Medical & biological engineering & computing,
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
July 2001,
Journal of applied physiology (Bethesda, Md. : 1985),
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
January 1967,
Journal de physiologie,
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
November 1973,
The Physiologist,
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
October 1972,
Kokyu to junkan. Respiration & circulation,
R B Salmon, and
G M Saidel, and
F P Primiano, and
D E Niewoehner, and
E H Chester
April 1990,
Kokyu to junkan. Respiration & circulation,
