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The biliary metabolites of 17 alpha-ethynyl[3H]estradiol (3H-EE2) and their enterohepatic circulation were studied in female rats. Rapid and extensive elimination of radioactivity in bile followed i.v. administration of 3H-EE2. The metabolites consisted largely of beta-glucuronides of 2-hydroxy-EE2 and, to a lesser extent, 2-methoxy-EE2. Intraduodenally infused radiolabelled biliary metabolites underwent enterohepatic circulation; 15 +/- 6% (mean +/- S.D., n = 4) of the 3H was excreted in the bile of the recipient rats in 5.5 h. The metabolites excreted by the recipients were qualitatively and quantitatively similar to the infused metabolites. The 1(4)-glutathione adduct of 2-hydroxy-EE2 was synthesized, but was not observed in either the donors' or recipients' bile.
J L Maggs, and
P S Grabowski, and
B K Park
January 1969,
Nihon Naibunpi Gakkai zasshi,
J L Maggs, and
P S Grabowski, and
B K Park
January 1972,
Journal of reproduction and fertility,
J L Maggs, and
P S Grabowski, and
B K Park
January 1990,
Xenobiotica; the fate of foreign compounds in biological systems,
J L Maggs, and
P S Grabowski, and
B K Park
March 1976,
British journal of pharmacology,
J L Maggs, and
P S Grabowski, and
B K Park
January 1980,
Arzneimittel-Forschung,
J L Maggs, and
P S Grabowski, and
B K Park
December 1969,
Bulletin de la Societe de chimie biologique,
J L Maggs, and
P S Grabowski, and
B K Park
August 1967,
Folia endocrinologica,
J L Maggs, and
P S Grabowski, and
B K Park
January 1989,
Drug metabolism and disposition: the biological fate of chemicals,
J L Maggs, and
P S Grabowski, and
B K Park
May 1980,
The Journal of pharmacology and experimental therapeutics,
J L Maggs, and
P S Grabowski, and
B K Park
April 1988,
Xenobiotica; the fate of foreign compounds in biological systems,
