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Comparative characteristics of the distribution of phophokinase-125I was studied in rats after the intravenous injection in free or liposome-entrapped state. Significant increase of protein entrapment by the organs and prolonged tissue retention (up to 6 days) were found after the liposomes administration as compared to injection of free material (no label was found after 24 hrs). Intracellular localisation of the label in the liver was revealed autoradiographically 24 hrs after the liposome injection; it was absent after its injection in free state. Enzyme assay in liver homogenates revealed intact specific activity after liposome administration, and confirmed the quantitative data obtained with radiolabeled protein.
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