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Male Wistar rats received 20 mg/kg/day of amikacin (AMK) with or without 200 mg/kg/day of fosfomycin (FOM) for 5 days. Accumulation of AMK in renal lysosome-containing fraction was inhibited by FOM. FOM was reported to interfere with the nephrotoxic properties of aminoglycosides. Our observation supports the finding.
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