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This study was carried out to compare the efficacy of chlormethiazole and chlordiazepoxide in the treatment of acute alcohol withdrawal syndrome in 40 patients. Repeated biochemical, clinical, and psychophysiological measurements were obtained in a randomized, double-blind design in which one group of patients received chlormethiazole and a second group received chlordiazepoxide over a period of 7 days. Analysis indicated both drugs to be of equivalent potency and were equally well tolerated by patients. The more severe aspects of withdrawal were brought under control within the first 4 days of treatment. However, even at 7 days, there still persisted some symptoms attributable to the withdrawal from alcohol.
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
April 1972,
Diseases of the nervous system,
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
February 1961,
Psychopharmacologia,
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
May 1988,
British journal of addiction,
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
January 1985,
Alcohol and alcoholism (Oxford, Oxfordshire),
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
April 1975,
The British journal of addiction to alcohol and other drugs,
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
August 1966,
Ugeskrift for laeger,
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
October 1969,
The British journal of psychiatry : the journal of mental science,
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
November 1965,
Wisconsin medical journal,
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
January 1986,
Acta psychiatrica Scandinavica. Supplementum,
Y D Lapierre, and
D R Bulmer, and
L K Oyewumi, and
M L Mauguin, and
V J Knott
February 1980,
British medical journal,
