-transparent.png){kind=logo}
1 The pharmacokinetics of neostigmine and pyridostigmine was studied in conscious dogs by the use of a cross-over design. 2 Both neostigmine and pyridostigmine were cleared from plasma in a biexponential manner. 3 The apparent volume of distribution of pyridostigmine was invariably greater than that of neostigmine, and its fast disposition half-life was approximately three times longer. 4 The whole body clearance and the urinary elimination of pyridostigmine was approximately twice that of neostigmine. 5 The slow disposition half-life of pyridostigmine was approximately three times longer than that of neostigmine, suggesting that the longer duration of action of pyridostigmine is related to the differential clearance of the two quarternary amines from plasma.
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
November 1973,
European journal of pharmacology,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
March 1980,
British journal of clinical pharmacology,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
August 1981,
British journal of anaesthesia,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
April 1980,
Methods and findings in experimental and clinical pharmacology,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
May 1973,
The Journal of pharmacy and pharmacology,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
November 1984,
Anesthesiology,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
August 1988,
Anesthesia and analgesia,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
May 1979,
Anesthesiology,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
January 1977,
Clinical and experimental neurology,
P R Baker, and
T N Calvey, and
K Chan, and
C M Macnee, and
K Taylor
May 1976,
Journal of chromatography,
