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The facile synthesis of [1,2,3]triazolo((4,5-d][2]benzazepines and dibenzo[c,f][1,2,3]triazolo[3,4-a]azepines by the addition of sodium azide to acetylenic benzophenones is described. Examination of the pharmacological data indicates that selected triazolobenzazepines are as potent as diazepam in the anti-pentylenetetrazole test and are weaker in the inclined screen and rotarod tests, suggesting that these compounds have antianxiety properties similar to diazepam with fewer deficits in motor coordination. In addition, a possible diazepam antagonist was found in the triazolo-benzazepine series. The dibenzotriazoloazepines were found to be inactive in four standard CNS screening procedures.
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L Benjamin, and
S Vitone, and
A Walser, and
R I Fryer
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European journal of medicinal chemistry,
E J Trybulski, and
L Benjamin, and
S Vitone, and
A Walser, and
R I Fryer
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E J Trybulski, and
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E J Trybulski, and
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E J Trybulski, and
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E J Trybulski, and
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E J Trybulski, and
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Farmaco (Societa chimica italiana : 1989),
