Biomaterial Database

Ontogeny of stress effects on ornithine decarboxylase activity in rats. 1983

C M Kuhn, and A Grignolo, and S M Schanberg

This study demonstrates that "stress" elicits a specific pattern of organ response in developing rats that is determined by the particular "stress" and by the age of the animal. Maternal deprivation (MD) of preweanling rat pups decreases ornithine decarboxylase (ODC) activity in many tissues, as reported previously, while immobilization (IMM) and cold stress increase ODC activity in liver and heart of neonatal rat. Serum GH is decreased by MD and by IMM, but is not affected by cold stress. Stress-induced ODC elevation increases with age, while MD effects disappear at weaning. IMM and cold increase ODC activity in kidney, liver and heart of adult rats. These effects of IMM are blocked by the ganglionic antagonist chlorisondamine in adult but not in neonatal rats. The results of this study suggest that MD and the "classical" stress paradigms IMM and cold evoke different patterns of organ ODC response in neonatal rats. Furthermore, these findings suggest that the mechanism by which immobilization increases ODC activity changes from a hormonal to a neural mechanism during ontogeny.

UI	MeSH Term	Description	Entries
D007774	Lactation	The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.	Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D008426	Maternal Deprivation	Prolonged separation of the offspring from the mother.	Deprivation, Maternal,Deprivations, Maternal,Maternal Deprivations
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D009955	Ornithine Decarboxylase	A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.	Ornithine Carboxy-lyase,Carboxy-lyase, Ornithine,Decarboxylase, Ornithine,Ornithine Carboxy lyase
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D012149	Restraint, Physical	Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION.	Immobilization, Physical,Physical Restraint,Physical Immobilization,Physical Restraints,Restraints, Physical
D002262	Carboxy-Lyases	Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.	Carboxy-Lyase,Decarboxylase,Decarboxylases,Carboxy Lyase,Carboxy Lyases
D002714	Chlorisondamine	A nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.	Chlorisondamine Chloride,Chlorisondamine Dichloride,Ecolid,Chloride, Chlorisondamine,Dichloride, Chlorisondamine
D003080	Cold Temperature	An absence of warmth or heat or a temperature notably below an accustomed norm.	Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D005260	Female		Females